Recurrent abdominal and lower limb venous thrombosis due to inherent protein-C and protein-S deficiency
نویسندگان
چکیده
منابع مشابه
Protein C deficiency and mesenteric venous thrombosis.
A 22-year-old woman with a history of gestational toxicosis and oral contraceptive use for 3 years reported progressive vague abdominal pain and vomiting over a 2-day period, without constipation, followed by rectal bleeding. On physical examination in the emergency department, the patient was afebrile, her blood pressure was 110/70 mm Hg and her pulse rate was 80 beats/min. There was diffuse a...
متن کاملFamilial protein S deficiency is associated with recurrent thrombosis.
Recent studies have demonstrated that protein C deficiency is associated with recurrent familial thrombosis. In plasma, activated protein C functions as an anticoagulant. This anticoagulant response requires a vitamin K-dependent plasma protein cofactor, referred to as protein S. Since the anticoagulant activity of activated protein C is dependent on protein S, we hypothesized that patients lac...
متن کاملThe risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S.
Few data are available on the risk of recurrent venous thromboembolism (VTE) associated with the rare inherited deficiencies of natural anticoagulants. We studied 602 patients with previous VTE: the incidence of first recurrence in the absence of anticoagulation was retrospectively estimated in 64 patients with deficiency of antithrombin (AT, n=14), protein C (PC, n=28), or protein S (PS, n=22)...
متن کاملIschemic stroke due to protein C deficiency.
Plasma protein C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism. However, arterial thrombosis has been only rarel...
متن کاملprotein c and s deficiency in deep vein thrombosis patients referred to iranian blood transfusion organization, kermanshah
introduction: normal homeostasis system has several inhibitor mechanisms in front of the amplifier’s natural clotting enzyme to prevent fibrin clots in the vessels. the main inhibitors of coagulation pathway are antithrombin (at), protein c and protein s. patients with hereditary deficiency of coagulation inhibitors are susceptible to venous thromboembolism (vte). one of the major clinical mani...
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ژورنال
عنوان ژورنال: International Journal of Research in Medical Sciences
سال: 2019
ISSN: 2320-6012,2320-6071
DOI: 10.18203/2320-6012.ijrms20193653